Colorectal cancer
| PAG Title | Colorectal cancer |
| PAG ID | WAG001616 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). Two major mechanisms of genomic instability have been identified in sporadic CRC progression. The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of oncogenes such as K-ras and ictivation of TSG such as p53, DCC/Smad4, and APC. The second, known as microsatellite instability (MSI), results from ictivation of the D mismatch repair genes MLH1 and/or MSH2 by hypermethylation of their promoter, and secondary mutation of genes with coding microsatellites, such as transforming growth factor receptor II (TGF-RII) and BAX. Hereditary syndromes have germline mutations in specific genes (mutation in the tumour suppressor gene APC on chromosome 5q in FAP, mutated D mismatch repair genes in HNPCC). |
| Species | Homo sapiens |
| nCoCo Score | 3,424 |
| Base PAG ID | WAG001616 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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